BMDExpress was created for the purpose of providing an easy workflow to transform toxicogenomic data into BenchMark Doses for aggregated collections of genes; KEGG pathways, GO terms, or user defined categories. The end results are parameterized curve fits of dose-response data for individual gene probes together with associated statistics, and a set of intuitive visualizations that simplify drilling into analysis results to yield an improved understanding of the biological response.
Productivity features include interactive, graphical, and dynamic visualizations that enable the user to view and quickly interpret analysis results. On-the-fly filtering enables quick application of constraints, yielding visualizations that zero in on the most important subsets of analysis results. Simultaneous visualization of multiple experiments provides for easy comparison of different chemical treatment conditions within the application interface.
BMDExpress is the product of an ongoing collaboration between the NIEHS Division of the NTP, Health Canada, US EPA, and Sciome LLC, with Sciome primarily responsible for designing and implementing the resulting software.