Sciome LLC is an innovative research and technology consulting company providing state of the art informatics solutions for the life sciences industry. We specialize in developing and deploying novel bioinformatics, cheminformatics, text-mining and data science solutions for researchers in government, academic and private sector organizations.
High throughput technologies are routinely used to study genomes, proteomes and metabolomes creating a deluge of scientific data. In addition, large volumes of data are available via electronic health records, clinical study reports, government reports, high content images, and the ever increasing amount of scientific literature in peer reviewed journals and on the World Wide Web. Success of scientific endeavors in such data rich environments greatly depends on the careful exploration and interpretation of this data. This has created a large demand for sophisticated tools and highly skilled expertise to enable data-driven discovery.
Our goal is to provide cutting edge, customized and cost effective informatics solutions for efficient data management, data analyses and interpretation. We develop novel quantitative methodologies, design and deliver intuitive software tools, and deploy efficient computational techniques to enable timely and insightful discoveries.
We use comprehensive and cutting edge quantitative methods paired with efficient informatics techniques to solve complex scientific challenges. We work with our clients at all stages of the life science discovery process, starting with hypotheses generation and experiment design, through data analysis using off-the-shelf and custom designed methodologies and culminating with expert help in interpretation of the results. We also provide detailed support for manuscript preparation, formulation of reports, and aid in the dissemination of information using print or online medium for projects that cover a variety of scientific disciplines. Our consulting team includes PhD level Bioinformatics Scientists, Statisticians, Cheminformaticians, Computational Toxicologists, Health Scientists and Computer Scientists with a wide array of experience in government contracting, academic research and the pharmaceutical industry.
We are a light hearted, hardworking, multi-disciplinary team of scientists who enjoy diverse technical challenges and love to work in a team. We share a passion for varied scientific disciplines and we love to learn, experiment and innovate.
We get hired to solve complex, unique and/or recurring scientific challenges. Our consulting engagements range from multiyear research endeavors in support of environmental or health related topics to short term data mining projects in support of specific scientific pursuits. We continue to serve a variety of US Federal Government agencies, pharmaceutical and biotechnology companies, non-profit research organizations and academic institutes.
SWIFT-Active Screener is a web-based, collaborative systematic review software application. Active Screener was designed to be easy-to-use, incorporating a simple, but powerful, graphical user interface with rich project status updates.
BMDExpress was created for the purpose of providing an easy workflow to transform toxicogenomic data into BenchMark Doses for aggregated collections of genes; KEGG pathways, GO terms, or user defined categories.
SWIFT-Review (SWIFT is an acronym for “Sciome Workbench for Interactive computer-Facilitated Text-mining”) is a freely available interactive workbench which provides numerous tools to assist with problem formulation and literature prioritization.
Comprehensive analysis of TempO-Seq data using novel, validated and robust bioinformatics methods. Upload raw Tempo-Seq data and instantaneously obtain in-depth analysis including cluster plots, principal component plots, differentially expressed gene list, and pathway analysis.
The Integrated Chemical Environment (ICE) provides high-quality, curated data from the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and its partners as well as other data resources and tools to support development of new approaches for assessing chemical safety.
OrbiTox presents Big Data in an intuitive, immersive, and fluid 3D environment. It is a one-of-a-kind computational translational discovery platform for interactive, 3D visualization of large (~million objects), high-dimensional (~1000 features), multidomain toxicology and drug discovery data.
Sciome employs a highly talented team of software engineers and scientific programmers. This development team works closely with Sciome scientists, mathematicians and statisticians to design and implement interactive software solutions that solve important problems on behalf of our clients.
Dunnick, J.K., Pandiri, A.R., Shockley, K.R., Herbert, R., Mav, D., Phadke, D., Shah, R.R. & Merrick, B.A. (2022). Single nucleotide polymorphism patterns associated with a cancer resistant phenotype. Experimental and Molecular Pathology, 104812 (Accepted, in press).
Blake, B., Miller, C.N., Nguyen, H., Phan, T.P., Phadke, D.P., Balik-Meisner, M.R., Mav, D., Shah, R.R. & Fenton, S.E. (2022). Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice. Ecotoxicology and Environmental Safety (Accepted, in press).
Tandon, A., Howard, B., Ramaiahgari, S., Maharana, A., Ferguson, S., Shah, R. & Merrick, A. (2022). Deep learning image analysis of high-throughput toxicology assay images. SLAS Discovery, 27(1), 27-38. PMCID: PMC8955414
Brandner, S., McAleenan, A., Jones, H.E., Kernohan, A., Robinson, T., Schmidt, L., Dawson, S., Kelly, C., Leal, E.S., Faulkner, C.L., Palmer, A., Wragg, C., Jefferies, S., Vale, L., Higgins, J.P.T. & Kurian, K.M. (2022). Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: a comprehensive meta-analysis based on a Cochrane systematic review. Neuropathology and Applied Neurobiology, 48(4), e12790. PMCID: PMC9208578
Brownstein, N.C., Cai, J., Smith, S., Diatchenko, L., Slade, G.D. & Bair, E. (2022). Modeling secondary phenotypes conditional on genotypes in case-control studies. Stats, 5(1), 203-214.
Everett LJ; Mav D; Phadke DP; Balik-Meisner M; Shah R.R. (2022). Impact of Aligner, Normalization Method, and Sequencing Depth on TempO-seq Accuracy. Bioinformatics and Biology Insights 16:1-12.
High-throughput transcriptomics has advanced through the introduction of TempO-seq, a targeted alternative to traditional RNA-seq. TempO-seq platforms use 50 nucleotide probes, each specifically designed to target a known transcript, thus allowing for reduced sequencing depth per sample compared with RNA-seq, without compromising the accuracy of results. Thus far, studies using
As part of the EUSAAT and ESTIV 2022 meetings, Dr. Ruchir Shah will present recent work on OrbiTox, an interactive 3D visualization and analysis platform for varied scientific big data with special emphasis on predictive toxicology. As the reliance on traditional animal testing is phasing out, new approach methodologies generate
As part of the EUSAAT and ESTIV 2022 meetings, Dr. Ignacio Tripodi will present recent research on turning Adverse Outcome Pathways (AOPs) into testable hypotheses with natural language processing (NLP) and tissue-specific knowledge graphs (KG). The AOP framework is crucial to the success of new approach methodologies (NAMs) for toxicity
2 Davis Drive
Research Triangle Park, NC 27709, USA
919-338-2177
1920 E NC 54 Hwy, Suite 510 & 520
Durham, NC 27713, USA
919-338-2177