As part of the EUSAAT and ESTIV 2022 meetings, Dr. Ruchir Shah will present recent work on OrbiTox, an interactive 3D visualization and analysis platform for varied scientific big data with special emphasis on predictive toxicology. As the reliance on traditional animal testing is phasing out, new approach methodologies generate massive amount of detailed data which are often difficult to utilize efficiently. Using novel data clustering, machine learning and visualization techniques, we have developed an interactive 3D environment which houses millions of scientific data points connected per known or predicted relationships among them, thus enabling easy access and toxicologically relevant knowledge extraction all in one intuitive user interface. Housing curated data from 900,000 substances, 22,000 human targets, 1,500 biological pathways, over 100 test organisms, and QSAR models for over 40 Tox21 assays and bacterial mutagenicity tests, OrbiTox allows querying from any domain. The technology underlying OrbiTox allows real-time data interaction and is readily scalable to several million data points. To our knowledge, the technology and functionality of OrbiTox is not available in any other existing data graph-visualizing frameworks.
Please join us to learn more about OrbiTox at The European Society for Alternatives to Animal Testing (EUSAAT) 2022 European Congress on Alternatives to Animal Testing on September 26-28 in Linz, Austria. EUSAAT is the European 3Rs Society, which actively promotes the protection of experimental animals according to the 3Rs-Principle (Replace, Reduce, Refine). The annual congress provides an opportunity to share scientific experience on alternatives to animal use in the life sciences as well as advanced in silico and in vitro methods.
Dr. Shah will also highlight OrbiTox at The 21st International Congress of the European Society of Toxicology In Vitro (ESTIV 2022) being held in Sitges, Spain November 21-25. ESTIV brings together researchers, toxicologists, and students engaged in the promotion of development of in vitro and in silico approaches from around the globe.