Each year, the International Medical Informatics Association (IMIA) Yearbook highlights notable papers in the field of Bioinformatics and Translational Informatics (BTI). After identifying 263 potential papers evaluated on their novelty, importance, and objective quality, Dr. Ignacio Tripodi’s MechSpy publication, Applying knowledge-driven mechanistic inference to toxicogenomics, was named one of 2020’s Top Translational Bioinformatics Publications.