The 11th edition of the World Congress on Alternatives and Animal Use in the Life Sciences, being held virtually from Aug 23-Sep 2 2021; will bring together scientists from around the world to discuss developments in the field of alternatives to animal testing in the life sciences. During the congress, Dr. Ruchir Shah will highlight work that the Sciome team has done (in collaboration with NIEHS) to:
- Develop a novel approach involving network analysis and 3D visualization to evaluate similarities between transcriptional signatures of chemicals. The team has applied this framework in conjunction with benchmark dose analysis to maximize knowledge acquisition. As a case study, the team evaluated liver TempO-Seq S1500+ transcriptomic data from rats exposed to the common environmental pollutant, perfluorooctanoic acid (PFOA).
- Implement Saagar, a compilation of molecular substructures for cheminformatics applications, including read-across assessments and interpretable Quantitative Structure-Property Relationship (QSPR) models. Saagar structural features have been systematically gathered by studying and reviewing available literature that highlights relationships between sub-structural moieties and a variety of physico-chemical, ADME (absorption, distribution, metabolism and excretion), and toxicological properties of molecules.